CureVac´s Optimized mRNA Platform Provides Positive Pre-Clinical Results at Low Dose for Coronavirus Vaccine Candidate

05-14-2020

Email Press Release PDF version

• CureVac’s mRNA platform demonstrated positive low dose results in multiple indications including Flu, RSV and in humans for Rabies
• Coronavirus lead vaccine candidate has generated high levels of virus neutralizing titers after two 2 microgram dose vaccinations in pre-clinical experiments
• GMP manufacturing of large quantities of drug-substance completed

TÜBINGEN, Germany/ BOSTON – May 14, 2020 – CureVac AG, a clinical-stage biopharmaceutical company developing a new class of transformative medicines based on optimized mRNA, today announced positive pre-clinical results at a low dose for its lead vaccine candidate against the novel Coronavirus (SARS-CoV-2). The data showed a fast induction of a balanced immune response with high levels of virus neutralizing titers (VNTs) and T-cell responses. VNTs are a major criterion supporting that the vaccine candidate has the potential to induce a strong immunologic response to neutralize SARS-CoV-2.
The results underline the strength of CureVac's mRNA technology platform and are in line with previously generated data in Rabies, Flu and Respiratory-Syncytial-Virus (RSV). In all such indications CureVac’s mRNA based vaccine candidates were active at low dose and protected animals from virus infection in established challenge models. Recently, the Company also tested the Rabies mRNA vaccine product candidate in a Phase 1 human clinical trial. The product candidate induced adaptive immune response as shown by protective levels of rabies-specific VNTs in all healthy volunteers who received two administrations of a dose of 1 microgram.
With regard to the Coronavirus vaccine candidate, upon publication of the sequence of the novel virus in January 2020, CureVac launched pre-clinical tests with a variety of potential antigenic constructs based on the spike protein to elicit high immunogenicity. The Company intends to initiate the first phase 1/2a clinical trial in healthy volunteers in June 2020 with its lead vaccine candidate.
CureVac has already produced large quantities of material for its vaccine candidate in its GMP III manufacturing facility in Tübingen (Germany). The manufacturing capacity of the facility can potentially supply several hundred million doses per year, depending on the human dose defined in the clinical trials.
Dr. Mariola Fotin-Mleczek, Chief Technology Officer of CureVac, says: “This pre-clinical data validates our strategy to leverage the promising results in healthy volunteers of our Rabies vaccine candidate shown in our ongoing clinical trial. It is remarkable that with both vaccine candidates - Rabies and Coronavirus - as well as with our Flu and RSV projects, we were able to achieve positive results at such a low dose. The outcomes demonstrate the potential of our mRNA technology platform to revolutionize the field of vaccines.”
Dr. Franz Werner-Haas, acting Chief Executive Officer and Chief Operating Officer, adds: “We have been working on our mRNA platform for almost two decades and are leveraging our deep scientific understanding of the technology. With recurring positive results for Flu, RSV, Rabies and now our Coronavirus vaccine candidate, we have demonstrated the sustained performance of our mRNA platform. We are convinced that with our expertise and advanced technology we are well positioned to fight viral outbreaks such as the current one and that our approach may provide the best chance to protect many people from SARS-CoV-2 and other health threats.”
The Company has received financial support for its Coronavirus vaccine development from the Coalition for Epidemic Preparedness Innovations (CEPI), the Bill & Melinda Gates Foundation as well as from the Defense Advanced Research Projects Agency (DARPA), an agency of the U.S. Department of Defense.
About CureVac’s mRNA technology platform
CureVac’s mRNA technology platform has shown potential in the development and production of mRNA based vaccines and therapeutics. CureVac’s RNAoptimizer platform aims to optimize the properties of mRNA medicines based on its three core pillars: protein design, mRNA optimization and mRNA delivery. The technology can be tailored to induce varying degrees of immune responses against specific protein antigens of choice, potentially providing potent prophylactic vaccines for the prevention of infectious diseases, such as Rabies, as well as immunotherapies for the treatment of cancer. The technology can also be adapted to avoid immune activation for purposes of protein therapy and antibodies, thereby providing potential new therapeutic modalities for patients suffering from a vast range of diseases.
About CureVac AG
CureVac is a leading clinical stage biotechnology company in the field of messenger RNA (mRNA) technology with 20 years of expertise in developing and optimizing this versatile molecule for medical purposes. The principle of CureVac's proprietary technology is the use of mRNA as a data carrier to instruct the human body to produce its own proteins capable of fighting a wide range of diseases. The company applies its technologies for the development of cancer therapies, antibody therapies, the treatment of rare diseases, and prophylactic vaccines. CureVac has received significant investments, amongst others from dievini Hopp BioTech holding and the Bill & Melinda Gates Foundation. CureVac has also entered into collaborations with multinational corporations and organizations, including Boehringer Ingelheim, Eli Lilly & Co, Genmab, CRISPR Therapeutics, the Bill & Melinda Gates Foundation, CEPI and others. CureVac is headquartered in Tübingen, Germany with sites in Frankfurt and Boston, USA.
For more information, please visit www.curevac.com or follow us on Twitter at @CureVacAG.
CureVac Media Contact
Thorsten Schüller, Corporate Communications
CureVac AG, Tübingen, Germany
T: +49 7071 9883-1577
thorsten.schueller@curevac.com



Betty MacDonald fan club fans,

Betty MacDonald Memorial Award Winner Wolfgang Hampel's very popular golden satirical book Satire ist mein Lieblingstier ( Satire is my favourite animal ) is available in 5 continents and on Amazon U.S. Best Sellers Rank in Parody. ( see list below )  

We have a golden Betty MacDonald fan club offer for you. 
Tell us your favourite satirical text of Wolfgang Hampel's book Satire ist mein Lieblingstier, please and you'll get several fascinating Betty MacDonald fan club items for free.
Wolfgang Hampel's very successful book is available in many countries around the world. ( see links below )
A wonderful Betty MacDonald fan club offer: You can win a first edition of one of Betty MacDonald's books with a dedication of Betty MacDonald. It's a golden treasure. 

Don't miss this unique Betty MacDonald fan club offer, please.
Send us a photo of your favourite flower, please.

You can win many very interesting Betty MacDonald fan club items.

Good luck!

Thank you so much for your interest and support.

Greetings,

Lisa 

Betty MacDonald fan club - and Vita Magica fans,

very witty book ' Satire ist mein Lieblingstier ' ( Satire is my favourite animal ) by Heidelberg author, Betty MacDonald fan club - and Vita Magica founder Wolfgang Hampel is successful around the world.
This very funny book written in German got readers in the U.S. and many other countries. 
Especially in these times we need golden laughter.
This wonderful book is the best medicine against bad mood. 


Das sehr witzige Buch ' Satire ist mein Lieblingstier '  des
Heidelberger Autors und Vita Magica Gründers  Wolfgang Hampel ist auf der ganzen Welt erfolgreich.
Das deutschsprachige Buch hat auch in den USA und vielen anderen Ländern seine Leser gefunden.
Gerade in diesen Zeiten dürfen wir das Lachen nicht verlernen.
Dieses wunderbare Buch ist die beste Medizin gegen schlechte Laune.



You can order Wolfgang Hampel 'Satire ist mein Lieblingstier' (Satire is my favourite animal) 


Germany 

Germany buecher.de 

Germany Hugendobel.de

Germany - jpc 

Germany - lehmanns media

Germany - Jokers  

Germany - Weltbild 

Betty MacDonald Memorial Award Winner Wolfgang Hampel's very popular golden satirical book Satire ist mein Lieblingstier ( Satire is my favourite animal ) is available in 5 continents and on Amazon U.S. Best Sellers Rank in Parody.
( see list below )  



We have a golden Betty MacDonald fan club  Egg for you. 

Tell us your favourite satirical text of Wolfgang Hampel's book Satire ist mein Lieblingstier, please and you'll get several fascinating Betty MacDonald fan club items for free.
Wolfgang Hampel's very successful book is available in many countries around the world. ( see links below )

A wonderful Betty MacDonald fan club egg: You can win a first edition of one of Betty MacDonald's books with a dedication of Betty MacDonald. It's a golden treasure. 

Don't miss this unique Betty MacDonald fan club offer, please. 



Thank you so much for your interest and support.

Greetings,

 
Astrid 

Betty MacDonald Memorial Award Winner Wolfgang Hampel's very popular golden satirical book Satire ist mein Lieblingstier ( Satire is my favourite animal ) is available in 5 continents and on Amazon U.S. Best Sellers Rank in Parody.
( see list below )  

Angelika Jung and Wolfgang Hampel in Marc Marshalls SWR 3 TV Sendung HERZSCHLAG-MOMENTE  am Samstag, den 3.  August 2019  21.50



Angelika Jung and Wolfgang Hampel in Marc Marshall's SWR 3 TV Show HERZSCHLAG-MOMENTE  on Saturday  3rd of August 2019  21.50



Angelika Jung and Wolfgang Hampel in Marc Marshall's SWR 3 TV Show HERZSCHLAG-MOMENTE  on Saturday  3rd of August 2019  21.50

Marc Marshall in SWR 3 TV ' Talk am See ' - HERZSCHLAG - MOMENTE 



Wolfgang Hampel's very witty book 'Satire ist mein Lieblingstier' ( Satire is my favourite animal ) is No 1 Buecher de TOP List.

Wolfgang Hampels sehr witziges Buch ' Satire ist mein Lieblingstier' ( Satire is my favourite animal ) ist No 1 Buecher de TOP Liste.


Many greetings - viele Grüße

Mats  

Germany 

Germany buecher.de 

Germany Hugendobel.de

Germany - jpc 

Germany - lehmanns media

Germany - Jokers  

Germany - Weltbild 

Translate this page

Ich habe dieses Buch gekauft, weil Krimi-Königin Ingrid Noll Wolfgang ... sehr, daß wir die monatliche literarische Veranstaltung Vita Magica von Wolfgang Hampel bald einmal besuchen können.

Wolfgang Hampel's Satire ist mein Lieblingstier in Buecher de TOP list 

• PROMOTED Weltbild Satire ist mein Lieblingstier - Satirische Gedichte. Wolfgang Hampel, - Buch

You can order Wolfgang Hampel 'Satire ist mein Lieblingstier' (Satire is my favourite animal) 

U.S.A.

United Kingdom 

Australia

Austria

Brazil  

Canada

Czechia

Denmark

Finland

France

Germany 

Germany buecher.de 

Germany Hugendobel.de

Germany - jpc 

Germany - lehmanns media

Germany - Jokers  

Germany - Weltbild 

Hungary

Italy 

Japan 

Mexico

Norway 

Poland

Poland  ceneo

Romania 

Singapore

Slovak Republic

Spain 

Sweden

Switzerland

The Netherlands 

The Netherlands - DODAX


Wolfgang Hampel - Satire ist mein Lieblingstier ( Satire is my favourite animal ) 

Informationen über die Kultveranstaltung "Vita Magica" der Akademie für Ältere in Heidelberg  

Wolfgang Hampel - Satire ist mein Lieblingstier ( Satire is my favourite animal ) 

The best president ever 

Roger Cicero - ESC winner 2007  

Many ESC fans from all over the world are so very sad because we lost Joy Fleming - one of the best singers ever. 

Betty MacDonald fan club founder Wolfgang Hampel sings  'Try to remember' especially for Betty MacDonald fan club organizer Linde Lund at Vita Magica September

you can join 

Betty MacDonald fan club

Betty MacDonald Society  

Vita Magica  

Eurovision Song Contest Fan Club 

 

Wolfgang Hampel - Betty MacDonald fan club - and Vita Magica Founder 

on Facebook

Vita Magica Betty MacDonald event with Wolfgang Hampel, Thomas Bödigheimer and Friedrich von Hoheneichen

Vita Magica 

Betty MacDonald 

Betty MacDonald fan club 

Betty MacDonald fan club Google Images

Betty MacDonald fan club on Facebook

Betty MacDonald forum  

Wolfgang Hampel - Wikipedia ( English ) 

Wolfgang Hampel - Wikipedia ( English ) - The Egg and I 

Wolfgang Hampel - Wikipedia ( Polski)   

Wolfgang Hampel - Wikipedia ( German )

Wolfgang Hampel - LinkFang ( German ) 

Wolfgang Hampel - Academic ( German )

Wolfgang Hampel -  cyclopaedia.net ( German ) 

Wolfgang Hampel - DBpedia  ( English / German )

Wolfgang Hampel - people check ( English ) 

Wolfgang Hampel - Memim ( English )

Vashon Island - Wikipedia ( German )

Wolfgang Hampel - Monica Sone - Wikipedia ( English )

Wolfgang Hampel - Ma and Pa Kettle - Wikipedia ( English )

Wolfgang Hampel - Ma and Pa Kettle - Wikipedia ( French ) 

Wolfgang Hampel - Mrs. Piggle-Wiggle - Wikipedia ( English)

Wolfgang Hampel in Florida State University

Betty MacDonald fan club founder Wolfgang Hampel 

Betty MacDonald fan club interviews on CD/DVD

Betty MacDonald fan club items 

Betty MacDonald fan club items  - comments

Betty MacDonald fan club - The Stove and I  
 
Betty MacDonald fan club groups 

Betty MacDonald fan club organizer Linde Lund

 
 

Satire ist mein Lieblingstier - ...

€8.96

medimops.de

+€1.00 shipping

By Google

Satire ist mein Lieblingstier - ...

€13.00

Hugendubel.de

Free shipping

By Yamondo

Satire ist mein Lieblingstier - ...

€13.00

Thalia

Free shipping

By Google

Satire ist mein Lieblingstier - ...

€13.00

buecher.de

Free shipping

By Google

Satire ist mein Lieblingstier - ...

€13.00

Weltbild.de

Free shipping

By smec

Search Results

Web results

Satire ist mein Lieblingstier - Satirische Gedichte ... - Amazon.de

https://www.amazon.de › Satire-mein-Lieblingstier-Info...

- Translate this page

Satire ist mein Lieblingstier - Satirische Gedichte: Mit Informationen über die Kultveranstaltung "Vita Magica" der Akademie für Ältere in Heidelberg | Wolfgang ...

Satire ist mein Lieblingstier - Satirische Gedichte ... - Buecher.de

https://www.buecher.de › ... › Lyrik & Theater › Lyrik › Gedichte

Satire ist mein Lieblingstier - Satirische Gedichte. Mit Informationen über die Kultveranstaltung Vita Magica der Akademie für Ältere in Heidelberg. Satire ist mein ...

Satire ist mein Lieblingstier - Satirische Gedichte Buch - Weltbild

https://www.weltbild.de › artikel › satire-ist-mein-lieblin...

Translate this page

Jul 17, 2018 - Bücher bei Weltbild.de: Jetzt Satire ist mein Lieblingstier - Satirische Gedichte von Wolfgang Hampel versandkostenfrei bestellen bei ...

Satire ist mein Lieblingstier - Satirische Gedichte ... - Lehmanns

https://www.lehmanns.de › ... › Humor / Satire

Translate this page

Satire ist mein Lieblingstier - Satirische Gedichte von Wolfgang Hampel (ISBN 978-3-95828-155-4) bestellen. Schnelle Lieferung, auch auf Rechnung ...

Wolfgang Hampel, Satire ist mein Lieblingstier - Vita Magica

wolfvitamagica.blogspot.com › 2018/08 › wolfgang-ha...

Translate this page

Aug 1, 2018 - Betty MacDonald fan club - and Vita Magica founder Wolfgang Hampel's new book ' Satire ist mein Lieblingstier ' ( Satire is my favourite ...

„Wolfgang Hampel, Satire ist mein Lieblingstier - Satirische ...

https://www.booklooker.de › Bücher › Wolfgang Hampel